Racial differences in relation between carotid and radial augmentation index☆
Received 29 September 2009; received in revised form 2 November 2009; accepted 2 December 2009. published online 21 January 2010.
Abstract
Background
Augmented central artery wave reflection is a cardiovascular disease risk factor. Augmentation index (AI) obtained from peripheral artery waveforms provides qualitatively similar information to AI from central artery waveforms. Little information is available, however, regarding the influence of racial difference in association between central and peripheral AI.
Methods
We studied 47 White adults (45±17yr, 20 women) and 94 age-matched Asian adults (45±14yr, 42 women).
Results
The White group was significantly taller than the Asian group, whereas there were no significant group differences in blood pressure and heart rate. Carotid and radial AI tended to be lower in White compared with Asian adults (P<0.10 for both). Such tendency disappeared when the difference in height was taken into account using ANCOVA (P=0.84 and P=0.77, respectively). Radial AI was strongly and positively correlated with carotid AI in White adults (r=0.75, P<0.0001) as well as in Asian adults (r=0.82, P<0.0001). The slope and intercept of linear regression line between radial and carotid AI of White adults were highly comparable with those of Asian adults.
Conclusion
AI in the conveniently located peripheral vasculature may provide a surrogate measure of central AI irrespective of difference in race (e.g., Asian vs. White populations).
aInstitute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan
bCardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA
cCenter for Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan
dGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Corresponding author. Institute for Human Science and Biomedical Engineering, the National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, Tsukuba, Ibaraki 305 8566, Japan. Tel.: +81 29 861 7138; fax: +81 29 861 6660.
☆ Grant support: JSPS Postdoctoral Fellowships for Research Abroad (JS) and NIH grant AG20966 (HT).
ABSTRACT