Artery Research
Volume 4, Issue 2 , Pages 52-58 , June 2010

Oxidative stress and arterial stiffness in strength- and endurance-trained athletes

  • Youngju Choi

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Seiji Maeda

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 29 853 2683; fax: +81 29 853 2986.
    • ,
  • Takeshi Otsuki

      Affiliations

    • Graduate School of Health and Sport Sciences, Ryutsu Keizai University, Ibaraki, Japan
    • ,
  • Asako Miyaki

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Nobutake Shimojo

      Affiliations

    • Division of Cardiovascular Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Mutsuko Yoshizawa

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Hitoshi Shiraki

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Ryuichi Ajisaka

      Affiliations

    • Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

Received 11 February 2010 ,Revised 23 April 2010 ,Accepted 29 April 2010.

References 

  1. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102:1270–1275
  2. Kakiyama T, Sugawara J, Murakami H, Maeda S, Kuno S, Matsuda M. Effects of short-term endurance training on aortic distensibility in young males. Med Sci Sports Exerc. 2005;37:267–271
  3. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, et al. Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men. Am J Physiol Heart Circ Physiol. 2007;292:786–791
  4. Bertovic DA, Waddell TK, Gatzka CD, Cameron JD, Dart AM, Kingwell BA. Muscular Strength training is associated with low arterial compliance and high pulse pressure. Hypertension. 1999;33:1385–1391
  5. Miyachi M, Kawano H, Sugawara J, Takahashi K, Hayashi K, Yamazaki K, et al. Unfavorable effects of resistance training on central arterial compliance. Circulation. 2004;110:2858–2863
  6. Cortez-Cooper MY, Devan A, Anton M, Farrar R, Beckwith K, Todd J, et al. Effects of high intensity resistance training on arterial stiffness and wave reflection in women. Am J Hypertens. 2005;18:930–934
  7. Kawano H, Tanimoto M, Yamamoto K, Sanada K, Gando Y, Tabata I, et al. Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp Physiol. 2008;93:296–302
  8. Miyachi M, Donato AJ, Yamamoto K, Takahashi K, Gates PE, Moreau KL, et al. Greater age-related reductions in central arterial compliance in resistance-trained men. Hypertension. 2003;41:130–135
  9. Okamoto T, Masuhara M, Ikuta K. Upper but not lower limb resistance training increases arterial stiffness in humans. Eur J Appl Physiol. 2009;107:127–134
  10. Rakobowchuk M, McGowan CL, Groot PC, Bruinsma D, Hartman JW, Phillips SM, et al. Effect of whole body resistance training on arterial compliance in young men. Exp Physiol. 2005;90:645–651
  11. Casey DP, Beck DT, Braith RW. Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection. Exp Biol Med. 2007;232:1228–1235
  12. Eskurza I, Monahan KD, Robinson JA, Seals DR. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physol. 2004;556:315–324
  13. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older man. J Appl Physiol. 2007;103:1715–1721
  14. Rodríguez-Mañas L, El-Assar M, Vallejo S, López-Dóriga P, Solís J, Petidier R, et al. Endothelial dysfunction in aged human is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8:226–238
  15. Pennathur S, Heinecke JW. Oxidative stress and endothelial dysfunction in vascular disease. Curr Diab Rep. 2007;7:257–264
  16. Wykretowicz A, Adamska K, Krauze T, Guzik P, Szczepanik A, Rutkowska A, et al. The plasma concentration of advanced oxidation protein products and arterial stiffness in apparently healthy adults. Free Radic Res. 2007;41:645–649
  17. Witko-Sarsat V, Friedlander M, Nguyen-Khoa T, Capeillere-Blandin C, Nguyen AT, Canteloup P, et al. Advanced oxidation protein products as native mediators of inflammation and monocyte activation in chronic renal failure. J Immunol. 1998;161:2524–2532
  18. Roman MJ, Devereux RB, Schwartz JE, Lockshin MD, Paget SA, Davis A, et al. Arterial stiffness in chronic inflammatory disease. Hypertension. 2005;46:194–199
  19. Kujala UM, Ahotupa M, Vasankari T, Kaprio J, Tikkanen MJ. Low LDL oxidation in veteran endurance athletes. Scand J Med Sci Sports. 1996;6:303–308
  20. Vasankari TJ, Kujala UM, Vasankari TM, Ahotupa M. Reduced oxidized LDL levels after a 10-month exercise program. Med Sci Sports Exerc. 1998;30:1496–1501
  21. Vasankari T, Lehtonen-Veromaa M, Möttönen T, Ahotupa M, Irjala K, Heinonen O, et al. Reduced mildly oxidized LDL in young female athletes. Atherosclerosis. 2000;151:399–405
  22. Selamoglu S, Turgay F, Kayatekin BM, Gonenc S, Yslegen C. Aerobic and anaerobic training effects on the antioxidant enzymes of the blood. Acta Physiol Hung. 2000;87:267–273
  23. Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis. 2003;167:327–334
  24. Cornelissen VA, Arnout J, Holvoet P, Fagard RH. Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age. J Hypertens. 2009;27:753–762
  25. Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Valle GD. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997;37:235–239
  26. Bergholm R, Mäkimattila S, Valkonen M, Liu ML, Lahdenperä S, Taskinen MR, et al. Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo. Atherosclerosis. 1999;145:341–349
  27. Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Haga S, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol. 2001;84:1–6
  28. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation. 2003;108:530–535
  29. Liu JF, Chang WY, Chan KH, Tsai WY, Lin CL, Hsu MC. Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters. Ann N Y Acad Sci. 2005;1042:255–261
  30. Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, et al. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radic Biol Med. 2007;43:901–910
  31. Cortez-Cooper MY, Supak JA, Tanaka H. A new device for automatic measurements of arterial stiffness and ankle-brachial index. Am J Cardiol. 2003;91:1519–1522
  32. Liu Z, Brin KP, Yin FC. Estimation of total arterial compliance: an improved method and evaluation of current methods. Am J Physiol Heart Circ Physiol. 1986;251:588–600
  33. Cameron JD, Dart AM. Exercise training increases total systemic arterial compliance in humans. Am J Physiol. 1994;266:693–701
  34. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, et al. Contribution of systemic arterial compliance and systemic vascular resistance to effective arterial elastance changes during exercise in humans. Acta Physiol. 2006;188:15–20
  35. Liu SX, Hou FF, Guo ZJ, Nagai R, Zhang WR, Liu ZQ, et al. Advanced oxidation protein products accelerate atherosclerosis through promoting oxidative stress and inflammation. Arterioscler Thromb Vasc Biol. 2006;26:1156–1162
  36. Seals DR. Habitual exercise and age-associated decline in large artery compliance. Exerc Sport Sci Rev. 2003;31:68–72
  37. Toikka JO, Niemi P, Ahotupa M, Niinikoski H, Viikari JS, Rönnemaa T, et al. Large-artery elastic properties in young men: relationships to serum lipoproteins and oxidized low-density lipoproteins. Arterioscler Thromb Vasc Biol. 1999;19:436–441
  38. Lee J, Goldfarb AH, Rescino MH, Hegde S, Patrick S, Apperson K. Eccentric exercise effect on blood oxidative stress markers and delayed onset of muscle soreness. Med Sci Sports Exerc. 2002;34:443–448
  39. Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res. 2005;19:276–285
  40. Bloomer RJ, Falvo MJ, Fry AC, Schilling BK, Smith WA, Moore CA. Oxidative stress response in trained men following repeated squats or sprints. Med Sci Sports Exerc. 2006;38:1436–1442
  41. Bloomer RJ, Fry AC, Falvo MJ, Moore CA. Protein carbonyls are acutely elevated following single set anaerobic exercise in resistance trained men. J Sci Med Sport. 2007;10:411–417
  42. Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology. 2003;189:41–54
  43. McBride JM, Kraemer WJ, Triplett-McBride T. Effect of resistance exercise on free radical production. Med Sci Sports Exerc. 1998;30:67–72
  44. Sahlin K, Cizinsky S, Warholm M. Repetitive static muscle contractions in humans: a trigger of metabolic and oxidative stress?. Eur J Appl Physiol Occup Physiol. 1992;64:228–236
  45. Franzoni F, Ghiadoni L, Galetta F, Plantinga Y, Lubrano V, Huang Y, et al. Physical activity, plasma antioxidant capacity, and endothelium-dependant vasodilation in young and older men. Am J Hypertens. 2005;18:510–516
  46. Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Haga S, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol. 2001;84:1–6
  47. Drueke T, Witko-Sarsat V, Massy Z, Descamps-Latscha B, Guerin AP, Marchais SJ, et al. Iron therapy, advanced oxidation protein products, and carotid intima-media thickness in end-stage renal disease. Circulation. 2002;106:2212–2217
  48. Kocak H, Gumuslu S, Sahin E, Ceken K, Gocmen YA, Yakupoglu G, et al. Advanced oxidative protein products are independently associated with endothelial function in peritoneal dialysis patients. Nephrology. 2009;14:273–280

PII: S1872-9312(10)00019-0

doi: 10.1016/j.artres.2010.04.002

Artery Research
Volume 4, Issue 2 , Pages 52-58 , June 2010

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