Artery Research
Volume 4, Issue 2 , Pages 59-65 , June 2010

Combined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis

  • Giulia Soloperto

      Affiliations

    • Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    • ,
  • Niall G. Keenan

      Affiliations

    • Cardiovascular Magnetic Resonance Unit, Royal Brompton & Harefield Trust, London, UK
    • ,
  • Mary N. Sheppard

      Affiliations

    • Department of Pathology, National Heart and Lung Institute, Imperial College London, UK
    • ,
  • Jacques Ohayon

      Affiliations

    • Engineering School Polytech Savoie, University of Savoie, France
    • ,
  • Nigel B. Wood

      Affiliations

    • Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 20 7594 5588; fax: +44 20 75941989.
    • ,
  • Dudley J. Pennell

      Affiliations

    • Cardiovascular Magnetic Resonance Unit, Royal Brompton & Harefield Trust, London, UK
    • ,
  • Raad H. Mohiaddin

      Affiliations

    • Cardiovascular Magnetic Resonance Unit, Royal Brompton & Harefield Trust, London, UK
    • ,
  • Xiao Yun Xu

      Affiliations

    • Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

Received 8 April 2010 ,Revised 4 May 2010 ,Accepted 7 May 2010.

References 

  1. Keenan NG, Pennell DJ. Cardiovascular magnetic resonance of the atheromatous plaque: achievements, anticipated developments, clinical application. In:  Rowlands D,  Clarke B editor. Recent advances in cardiology. London, UK: Royal Society of Medicine Press; 2008;p. 185–201
  2. Slager CJ, Wentzel JJ, Gijsen FJH, Thury A, van der Wal AC, Schaar JA, et al. The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications. Nat Clin Pract Cardiovasc Med. 2005;2:456–464
  3. Ohayon J, Finet G, Gharib AM, Herzka DA, Tracqui P, Heroux J, et al. Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol. 2008;295:H717–H727
  4. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–1375
  5. Groen H, Gijsen FJH, van der Lugt A, Ferguson MS, Hatsukami T, van der Steen AFW, et al. Plaque rupture in the carotid artery is localized at the high shear stress region: a case report. Stroke. 2007;38:2379–2381
  6. Slager C, Wentzel J, Gijsen FJH, Schuurbiers JCH, van der Wal AC, van der Steen AFW, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat Clin Pract Cardiovasc Med. 2005;2:401–407
  7. Tan FPP, Soloperto G, Bashford S, Wood NB, Thom S, Hughes A, et al. Analysis of flow disturbance in a stenosed carotid artery bifurcation using two-equation transitional and turbulence models. J Biomech Eng. 2008;130:061008-1–061008-12
  8. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–874
  9. Lovett JK, Gallagher PJ, Hands LJ, Walton J, Rothwell PM. Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation. 2004;110:2190–2197
  10. Lovett JK, Rothwell PM. Site of carotid plaque ulceration in relation to direction of blood flow: an angiographic and pathological study. Cerebrovasc Dis. 2003;16:369–375
  11. Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, et al. Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol. 2005;25:234–239
  12. Jackson M, Wood NB, Zhao S, Augst A, Wolfe JH, Gedroyc WMW, et al. Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts. Artery Res. 2009;3:32–38
  13. Keenan NG, Sheppard M, Nott D, Pennell DJ, Mohiaddin RH. Carotid plaque rupture. Lancet. 2009;374:1703
  14. Cai J-M, Hatsukami T, Ferguson M, Small R, Polissar N, Yuan C. Multicontrast magnetic resonance imaging classification of human carotid atherosclerotic lesions with in vivo. Circulation. 2002;106:1368–1373
  15. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999;282:2035–2042
  16. Li YS, Haga JH, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005;38:1949–1971
  17. Tricot O, Mallat Z, Heymes C, Belmin J, Lesèche G, Tedgui A. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation. 2000;101:2450–2453
  18. Brooks AR, Lelkes PI, Rubanyi GM. Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flow. Physiol Genomics. 2002;9:27–41
  19. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, et al. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004;101:14871–14876

PII: S1872-9312(10)00020-7

doi: 10.1016/j.artres.2010.05.001

Artery Research
Volume 4, Issue 2 , Pages 59-65 , June 2010

Article Tools

* Image Usage & Resolution