Artery Research
Volume 4, Issue 3 , Pages 91-93 , September 2010

Correlation between fetuin-A and matrix Gla protein levels in human serum

  • Katsuhito Mori

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6645 3806; fax: +81 6 6645 3808.
  • ,
  • Yuji Ikari

      Affiliations

    • The Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan
  • ,
  • Shuichi Jono

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Masanori Emoto

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Atsushi Shioi

      Affiliations

    • The Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
  • ,
  • Hidenori Koyama

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Tetsuo Shoji

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Eiji Ishimura

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Masaaki Inaba

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
  • ,
  • Kazuhiro Hara

      Affiliations

    • The Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan
  • ,
  • Yoshiki Nishizawa

      Affiliations

    • The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan

Received 16 March 2010 ,Revised 27 May 2010 ,Accepted 7 June 2010.

References 

  1. Ketteler M, Westenfeld R, Schlieper G, Brandenburg V. Pathogenesis of vascular calcification in dialysis patients. Clin Exp Nephrol. 2005;9:265–270
  2. Mori K, Ikari Y, Jono S, Emoto M, Shioi A, Koyama H, et al. Fetuin-A is associated with calcified coronary artery disease. Cor Art Dis, in press.
  3. Emoto M, Mori K, Lee E, Kawano N, Yamazaki Y, Tsuchikura S, et al. Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus. Metabolism. 2010;59:873–878
  4. Jahnen-Dechent W, Schafer C, Ketteler M, McKee MD. Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 2008;86:379–389
  5. Jono S, Ikari Y, Vermeer C, Dissel P, Hasegawa K, Shioi A, et al. Matrix gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Haemost. 2004;91:790–794
  6. Price PA, Thomas GR, Pardini AW, Figueira WF, Caputo JM, Williamson MK. Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. J Biol Chem. 2002;277:3926–3934
  7. Matsui I, Hamano T, Mikami S, Fujii N, Takabatake Y, Nagasawa Y, et al. Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure. Kidney Int. 2009;75:915–928
  8. Smith ER, Ford ML, Tomlinson LA, Rocks BF, Rajkumar C, Holt SG. Poor agreement between commercial ELISAs for plasma fetuin-A: An effect of protein glycosylation? Clin Chim Acta, in press.

PII: S1872-9312(10)00022-0

doi: 10.1016/j.artres.2010.06.002

Artery Research
Volume 4, Issue 3 , Pages 91-93 , September 2010