Artery Research
Volume 4, Issue 3 , Pages 81-90 , September 2010

Role of aortic calcification, stiffness and wave reflections in cardiovascular risk in dialysis patients: Baseline data from the CORD study

  • Francis Verbeke

      Affiliations

    • Department of Internal Medicine, Nephrology Section, Gent University Hospital, Gent, Belgium
    • Corresponding Author InformationCorresponding author at: Gent University Hospital, Department of Internal Medicine, Nephrology section, De Pintelaan 185, B-9000 Gent, Belgium. Tel.: +32 9 332 45 12; fax: +32 9 332 38 47.
  • ,
  • Raymond Vanholder

      Affiliations

    • Department of Internal Medicine, Nephrology Section, Gent University Hospital, Gent, Belgium
  • ,
  • Pieter L. Rensma

      Affiliations

    • Department of Nephrology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands
  • ,
  • Björn Wikström

      Affiliations

    • Renal Section, Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
  • ,
  • Per Bruno Jensen

      Affiliations

    • Department of Nephrology, Odense University Hospital, Odense, Denmark
  • ,
  • Jean-Marie Krzesinski

      Affiliations

    • Department of Nephrology, Liege University Hospital, Liege, Belgium
  • ,
  • Merete Rasmussen

      Affiliations

    • Genzyme A/S, Copenhagen, Denmark
  • ,
  • Wim Van Biesen

      Affiliations

    • Department of Internal Medicine, Nephrology Section, Gent University Hospital, Gent, Belgium
  • ,
  • Eero Honkanen

      Affiliations

    • Division of Nephrology Helsinki University Central Hospital, Helsinki, Finland
  • ,
  • on behalf of the CORD Study investigators

Received 23 April 2010 ,Revised 9 June 2010 ,Accepted 17 June 2010.

References 

  1. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004;15:2857–2867
  2. Yang H, Curinga G, Giachelli CM. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int. 2004;66:2293–2299
  3. Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP, Wilson PW. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis. 1997;132:245–250
  4. Bellasi A, Ferramosca E, Muntner P, Ratti C, Wildman RP, Block GA, et al. Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients. Kidney Int. 2006;70:1623–1628
  5. Wilson PW, Kauppila LI, O’Donnell CJ, Kiel DP, Hannan M, Polak JM, et al. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001;103:1529–1534
  6. Karamanoglu M, O’Rourke MF, Avolio AP, Kelly RP. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man. Eur Heart J. 1993;14:160–167
  7. Honkanen E, Kauppila L, Wikstrom B, Rensma PL, Krzesinski JM, Aasarod K, et al. Abdominal aortic calcification in dialysis patients: results of the CORD study. Nephrol Dial Transpl. 2008;23:4009–4015
  8. Hemmelgarn BR, Manns BJ, Quan H, Ghali WA. Adapting the Charlson Comorbidity index for use in patients with ESRD. Am J Kidney Dis. 2003;42:125–132
  9. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999;99:2434–2439
  10. London GM, Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME. Arterial wave reflections and survival in end-stage renal failure. Hypertension. 2001;38:434–438
  11. McEniery CM, Yasmin , Hall IR, Qasem A, Wilkinson IB, Cockcroft JR. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005;46:1753–1760
  12. Verbeke F, Van Biesen W, Peeters P, Van Bortel LM, Vanholder RC. Arterial stiffness and wave reflections in renal transplant recipients. Nephrol Dial Transplant. 2007;22:3021–3027
  13. Hecking E, Bragg-Gresham JL, Rayner HC, Pisoni RL, Andreucci VE, Combe C, et al. Haemodialysis prescription, adherence and nutritional indicators in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transpl. 2004;19:100–107
  14. Huybrechts KF, Caro JJ, London GM. Modeling the implications of changes in vascular calcification in patients on hemodialysis. Kidney Int. 2005;67:1532–1538
  15. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336–1345
  16. Willum-Hansen T, Staessen J, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation. 2006;113:664–670
  17. Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006;113:1213–1225
  18. Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–1953
  19. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605
  20. Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32:S112–S119
  21. Odink AE, Mattace-Raso FU, van der Lugt A, Hofman A, Hunink MG, Breteler MM, et al. The association of arterial stiffness and arterial calcification: the Rotterdam study. J Hum Hypertens. 2008;22:205–207
  22. McEniery CM, McDonnell BJ, So A, Aitken S, Bolton CE, Munnery M, et al. Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals. Hypertension. 2009;53:524–531
  23. Raggi P, Bellasi A, Ferramosca E, Islam T, Muntner P, Block GA. Association of pulse wave velocity with vascular and valvular calcification in hemodialysis patients. Kidney Int. 2007;71:802–807
  24. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transpl. 2003;18:1731–1740

PII: S1872-9312(10)00037-2

doi: 10.1016/j.artres.2010.06.004

Artery Research
Volume 4, Issue 3 , Pages 81-90 , September 2010