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Editorial Board
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IFC
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| Invited Speaker Extended Review Papers |
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Blood pressure variability and arterial stiffness
31 October 2011
Abstract: Blood pressure variability (BPV) is defined by the standard deviation of a given sample of population of normotensive or hypertensive subjects. Recent studies have suggested that this parame...
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Michel E. Safar
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119-121
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Regulation of arterial stiffness: Cellular, molecular and neurogenic mechanisms
07 November 2011
Abstract: The lasting legacy of Donald McDonald has been in the establishment of physiological and biophysical principles of the relation of blood pressure and flow in arteries. This relation is deter...
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Alberto Avolio,
Mark Butlin,
Ying-Yi Liu,
Kayla Viegas,
Bhargava Avadhanam,
George Lindesay
et al.
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122-127
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| Invited Speaker Abstracts |
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New insights in ultrasound imaging for cardiovascular diseases and large arteries properties
Recent developments of ultrafast ultrasound imaging scanners open very exciting possibilities in the field of cardiovascular imaging. Thanks to the new design of the most recent ultrasound scanners th...
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Mathias Fink
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128
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Vascular biomechanics: constitutive modelling and characterisation of the arterial wall
Insight into the mechanical properties of the arterial wall can give valuable information concerning the understanding of pulse wave propagation in the arterial tree, the genesis and progress of ather...
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F.N. van de Vosse
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128
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New insight in coronary vulnerable plaque mechanical properties
Vulnerable coronary atherosclerotic plaque rupture is a recognized major cause of acute coronary syndrome. Such vulnerable plaques can be detected clinically by various techniques, including intravasc...
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G. Finet,
J. Ohayon,
Gilles Rioufol
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128-129
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MRI in carotid plaque
The emergence of high-resolution imaging methods has enabled MRI to noninvasively image the fine internal structure of cervical arterial walls. This presentation will provide a comprehensive guide to ...
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C. Oppenheim,
E. Touzé
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129
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What is the future for research in arterial stiffness and central blood pressure ?
Please see Invited Speaker Extended Review Papers section.
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Michel E. Safar
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129
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Molecular mechanisms of the vascular repsonses to haemodynamic forces
Numerous studies in man and in animals support the relation between low or turbulent shear stress and atherosclerotic plaque location. However, little is known regarding the role of shear stress on th...
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S. Lehoux
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129
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Vascular Remodelling of the Retinal Microcirculation in Hypertension and Diabetes
In addition to the classical signs of hypertensive nephropathy (e.g. arterial narrowing, arterial venous nicking, retinal haemorrhages or microaneurysms) new technologies have emerged to characterize ...
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Roland E. Schmieder
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129
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Regulation of arterial stiffness: cellular, molecular and neurogenic mechanisms
Please see Invited Speaker Extended Review Papers section.
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Alberto Avolio
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129
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| Career Development Extended Review Paper |
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Author(s) |
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Advances in arterial stiffness assessment
07 November 2011
Abstract: Although the clinical relevance of arterial stiffness is increasingly recognized, the applicability of arterial stiffness for individual cardiovascular risk assessment is hampered due to tec...
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Evelien Hermeling,
Robert S. Reneman,
Arnold P.G. Hoeks,
Koen D. Reesink
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130-136
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| Career Development Abstracts |
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Author(s) |
Pages |
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Advances in Arterial Stiffness Assessment
Please see Career Development Extended Review Paper section.
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Evelien Hermeling
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137
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Large artery remodelling and stiffening in moderate chronic kidney disease
Chronic kidney disease (CKD) is characterized by a very high cardiovascular risk even at moderate stage. Patients with CKD are exposed to traditional cardiovascular factors and to uremia-associated CV...
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Marie Briet
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137
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Inflammation and large arteries
Firstly, we demonstrated that RA is associated with increased aortic stiffness compared with healthy controls, and that aortic stiffness correlates with current, but not historical measures of inflamm...
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Kaisa Maki-Petaja
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137
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| Oral Presentation Abstracts |
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Prognostic value of combined assessment of aortic stiffness and calcification in dialysis patients: Outcome data of the calcification outcome in renal disease (cord) study
Radiographic calcification and arterial stiffness each individually have been shown to predict outcome in dialysis patients. However, it remains unknown whether combined assessment of these markers of...
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F. Verbeke,
W. Van Biesen,
E. Honkanen,
B. Wikström,
P.B. Jensen,
J.M. Krzesinski,
M. Rasmussen,
R. Vanholder,
P.L. Rensma
et al.
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138
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Differential impacts of hypertension and type 2 diabetes mellitus on arterial disease and cardiovascular outcomes: The strong heart study
Background: Both hypertension and diabetes mellitus (DM) increase risk for subclinical and clinical cardiovascular disease (CVD). The relative extents to which hypertension and DM induce subclinical C...
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M. Roman,
B. Howard,
J. Kizer,
E. Lee,
L. Best,
R. Devereux
et al.
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138
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Prognostic value of carotid-femoral pulse wave velocity for cardiovascular events: An IPD meta-analysis of prospective observational data from 14 studies including 16,358 subjects
We have undertaken an individual participant data (IPD) meta-analysis of carotid-femoral pulse wave velocity (cf-PWV) with all cause mortality, CHD, stroke and combined CVD events using data from 14 s...
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Y. Ben-Shlomo,
M. Spears,
C. Boustred,
M. May,
S. Anderson,
P. Boutouyrie,
J. Cameron,
C.H. Chen,
J.R. Cockcroft,
K. Cruickshank,
S.J. Hwang,
E. Lakatta,
S. Laurent,
J. Maldonado,
C.M. McEniery,
G. Mitchell,
S. Najjar,
A. Newman,
M. Ohishi,
B. Pannier,
T. Pereira,
T. Shokawa,
K. Sutton-Tyrell,
D. Webb,
T. Willum-Hansen,
S. Zoungas,
I.B. Wilkinson
et al.
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138-139
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Pulse wave velocity and incident heart failure in chronic kidney disease
Heart failure (HF) complicates chronic kidney disease (CKD) despite improving medical therapy for co-morbidities like hypertension. We hypothesized that vascular stiffness, (aortic pulse wave velocity...
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R.R. Townsend,
A. Sheridan,
J. Strelsin,
M.J. Duckworth,
J.A. Chirinos,
V. Teal,
A. Khan,
J. Kusek,
M. Schreiber,
N. Bansal,
A. Ojo,
J.P. Lash,
M.M. Joffe,
C.R.I.C. Investigators
et al.
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139
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Aortic stiffness is independently associated with fatal and non-fatal cardiovascular events in chronic kidney disease stage 2-5
Objective: Chronic kidney disease (CKD) is characterized by a high cardiovascular risk. Subclinical damage to large arteries has been largely described in CKD and is mostly characterized by an increas...
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A. Karras,
J.P. Haymann,
S. Laurent,
E. Bozec,
B. Stengel,
C. Jacquot,
P. Houillier,
M. Froissart,
P. Boutouyrie,
M. Briet
et al.
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139-140
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Arterial stiffness is an independent determinant of compensatory hyperfiltration after kidney donation
After kidney donation, the remaining kidney tends to hyperfiltrate thus limiting the initial loss of renal function. However, the potential determinants of this compensative hyperfiltration (CHF) and ...
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P. Fesler,
J. Ribstein,
G. du Cailar,
G. Mourad,
A. Mimran
et al.
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140
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Pre-pregnancy cardiovascular risk in women with previous preeclampsia (PET)/intrauterine growth restriction (IUGR)
Women with history of preeclampsia (PET) and delivery of intrauterine growth restriction (IUGR) babies are at increased risk of cardiovascular events later in life. This could be related to endothelia...
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A.A. Mahendru,
C.C. Lees,
T.R. Everett,
C.M. McEniery,
I.B. Wilkinson
et al.
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140
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Spectral analysis of carotid distension rate and R–R interval (spontaneous baroreflex activity) predicts coronary heart disease risk in patients with moderate chronic kidney disease and in those with normal renal function: the EPP3 study
The classic technique to evaluate the spontaneous baroreflex is the spectral analysis of finger blood pressure and heart rate. However, baroreceptors respond to deformation and not to pressure per se ...
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L. Zanoli,
M. Alivon,
J.P. Empana,
N. Estrugo,
G. Ecriou,
H. Ketthab,
J.F. Pruny,
P. Castellino,
S. Yanes,
D. Laude,
K. Bean,
F. Thomas,
X. Jouven,
S. Laurent,
P. Boutouyrie
et al.
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140-141
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Normal and reference values for carotid intima-media thickness
Increased carotid artery intima-media thickness (IMT) has been widely used as a surrogate marker of atherosclerosis and has been shown to predict cardiovascular disease (CVD). However, the interpretat...
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L. Engelen,
P. Boutouyrie,
I. Ferreira,
C. Stehouwer,
S. Laurent
et al.
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141
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Establishing reference values for central blood pressure in a general healthy population and established disease groups
Background and Objective: Estimated central blood pressure is a non-invasive outcome regarded as a prognostic marker of cardiovascular disease. Reference values have been calculated previously in spec...
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A. Herbert,
Reference Values for Arterial Stiffness Collaboration
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141
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Differential effects of BNP and no donors on human forearm muscular conduit arteries
Nitroglycerin (NTG) selectively vasodilates muscular conduit arteries. Whether other nitric oxide (NO) donors and natriuretic peptides have similar effects is unknown. The aim of this study was to com...
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H. Fok,
B. Jiang,
A. Donald,
P. Chowienczyk
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141-142
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The “marathon paradox”: Decreased intima-media thickness and improved flow-mediated dilatation, but increased aortic stiffness
Background: Arterial stiffness, wave reflections, endothelial dysfunction and carotid intima-media thickness (cIMT) are predictors of cardiovascular events. Marathon running is an extremely vigorous a...
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D. Kardara,
C. Vlachopoulos,
D. Terentes-Printzios,
P. Xaplanteris,
N. Ioakeimidis,
C. Stefanadis
et al.
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142
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Common carotid artery properties are related to sympathetic outflow and cardiovascular variability
Objective: The relationship between sympathetic activity and common carotid artery (CCA) properties is unknown. We therefore tested the hypothesis that mechanical properties of arterial wall are indep...
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D. Hering,
K. Czechowicz,
R. Nowak,
W. Kucharska,
P. Brands,
P. Boutouyrie,
S. Laurent,
K. Narkiewicz
et al.
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142
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Arterial stiffness is a major independent determinant of visit-to-visit variability in SBP: A 9.1 year follow-up in treated hypertensives
Objective and background: Aortic stiffening, which favours the wave propagation generated by changes in cardiac output, and exaggerates the early return of wave reflection generated by changes in vaso...
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V. Nguyen,
C. Collin,
J. Varinot,
P. Boutouyrie,
S. Laurent
et al.
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142
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Distance measurement for pulse wave velocity calculation – Comparison with invasive findings
Background: A more simple yet accurate method for assessing travel distance (TD) for calculation of carotid-femoral pulse wave velocity (cfPWV) is desirable to improve acceptance of the method in clin...
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T. Weber,
A. Haiden,
S. Wassertheurer,
C.C. Mayer,
B. Hametner,
J. Kropf,
B. Eber
et al.
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142-143
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Lifetime adherence to a Mediterranean diet (MD) pattern is associated with lower carotid stiffness in young adults: The Amsterdam growth and health longitudinal study
Purpose: To investigate whether lifetime adherence to an MD pattern (i.e., from adolescence to adulthood) is associated with arterial stiffness in adults.
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R.J.J.M. van de Laar,
C.D.A. Stehouwer,
B.C.T. van Bussel,
M.H. Prins,
J.W.R. Twisk,
I. Ferreira
et al.
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143
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Impact of urban versus rural environment on central blood pressure, aortic stiffness and wave reflections: The PURSE-HIS study
Urbanisation of developing countries has had a marked impact on population health. In particular, in India, the prevalence of coronary heart disease is markedly increased in urban versus rural setting...
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S. Thanikachalam,
V. Harivanzan,
S. Ramasamy,
C.M. McEniery
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143-144
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Independent relation between ethnicity, baseline haemostatic variables, arterial stiffness and mortality: A 22-year follow-up study
Objectives: To examine the relationship between haemostatic factors, pulse wave velocity (PWV), blood pressure (BP) and mortality in British Europeans, African-Caribbeans (AfC) and Gujarati Indians.
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S.G. Anderson,
A.H. Heald,
J.K. Cruickshank
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144
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Unsupervised non-invasive measurement of aortic pulse transit time by means of electrical impedance tomography
Objectives: This study provides first experimental evidence on the feasibility of measuring Pulse Transit Time (PTT) values within the aorta by means of non-invasive and non-obtrusive Electrical Imped...
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J. Solà,
A. Adler,
A. Santos,
G. Tusman,
F. Suárez Sipmann,
S.H. Bohm
et al.
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144
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Predicting the functional impact of residual aortic coarctation lesions during exercise using advanced computer model simulations
Background: Exercise can be used to unmask the functional impact of a residual narrowing and/or stiffening following treatment of aortic coarctation. Measurements of the hemodynamic response during ex...
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L. Taelman,
J. Degroote,
J. Bols,
V. Muthurangu,
S. Panzer,
A. Swillens,
J. Vierendeels,
P. Segers
et al.
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144-145
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Oxidative stress and inflammation: Implication in endothelial dysfunction and cardiovascular aging on murine models
The aim of the study was to characterize cardiovascular aging with functional (Doppler) and molecular (RT-qPCR and immunohistochemistry quantifications) approaches using three murine models. Molecular...
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S. Baron,
T. Bedarida,
M.M. Strelcyn,
C.H. Cottart,
F. Vibert,
G. Renault,
B. Saubamea,
E. Veissieres,
D. Henrion,
J.L. Beaudeux,
V. Nivet-Antoine
et al.
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145
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Cardiotrophin-1 induces structural and mechanical changes in aorta
Aims: Cardiotrophin-1 (CT-1), a cytokine belonging to the interleukin-6 family, exerts proliferative and secretory effects in vascular smooth muscle cells. We investigated the morphological, micromech...
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R. Akhtar,
N. López-Andrés,
C. Labat,
J. Díez,
F. Zannad,
X. Zhao,
B. Derby,
J.K. Cruickshank,
P. Lacolley,
P. Rossignol
et al.
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145
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Acute β-adrenergic blockade increases aortic wave reflection in young men and women: Differing mechanisms between sexes
Acute β-adrenergic blockade increases aortic wave reflection, however, the mechanisms remain unclear. Evidence suggests that β-adrenergic receptor sensitivity in the peripheral vasculature differs bet...
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D.P. Casey,
T.B. Curry,
M.J. Joyner,
N. Charkoudian,
J.N. Barnes,
E.C. Hart
et al.
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145-146
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Relation between blood flow and arteriolar morphology and reduced vasodilatory capacity in hypertenisive patients with increased arteriolar wall-to-lumen ratio in the human retinal circulation in vivo
Objective: We hypothesized that blood flow and arteriolar morphological changes are related to each other in the human retinal vascular bed.
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M. Ritt,
J.M. Harazny,
C.H. Ott,
U. Raff,
G. Michelson,
R.E. Schmieder
et al.
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146
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Impact of 3D culture of mesenchymal stem cells to repair expanding AAAS
Abdominal aortic aneurysms (AAAs) are characterized by extracellular matrix degradation and mesenchymal cells rarefaction. In this context, the use of mesenchymal stem cells (MSCs) opens the way for t...
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F. Mohand-Kaci,
N. Assoul,
R. Bosc,
E. Allaire,
M. Zidi
et al.
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146
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In which extent gamma-glutamyltransferase contributes to the vasorelaxant effect of s-nitrosoglutathione?
S-nitrosoglutathione (GSNO) exhibits higher stability than nitric oxide (•NO) and plays an important role in vasoreactivity as it serves as •NO storage and transport, and is a source for protein nitro...
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F. Dahboul,
C. Perrin-Sarrado,
K. Maguin Gate,
A. Boudier,
C. Gaucher-di Stasio,
P. Liminana,
I. Lartaud,
A. Pompella,
P. Leroy
et al.
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146-147
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Microcirculation abnormalities as related to arterial stiffness and central blood pressure in hypertensive patients
Background: The possible relationships between indicators of small resistance artery structure and of large artery distensibility have not yet been evaluated. Aim: to assess the relationship between c...
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M.L. Muiesan,
D. Rizzoni,
M. Salvetti,
A. Paini,
C. Agabiti Rosei,
C. Aggiusti,
F. Bertacchini,
F. Beschi,
A. Agazzi,
E. Porteri,
C. De Ciuceis,
E. Agabiti Rosei
et al.
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147
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The information contained in wave reflection
Wave reflection associates with cardiovascular events. However, it is less clear what information on arterial function, such as arterial stiffness and vascular resistance, can be derived. We therefore...
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N. Westerhof,
B.E. Westerhof
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147
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Using finite element analysis to model acoustic radiation force imaging (ARFI) of carotid artery plaques
The sudden rupture of carotid artery plaques can trigger an ischemic stroke event and eventually lead to death. Unfortunately, the identification of unstable plaques continues to elude clinicians. The...
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J.R. Doherty,
D.M. Dumont,
M.L. Palmeri,
G.E. Trahey
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147-148
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Tissue factor pathway inhibitor: A new link between arterial stiffness, pulse pressure and coagulation in postmenopausal women
Objective: To investigate in women over 60 whether aortic stiffness and/or pulse pressure (PP) are associated with selected procoagulant and/or anticoagulant factors, and to examine whether pulsatile ...
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V. Regnault,
A. Kearney-Schwartz,
H. Louis,
B. Pannier,
A. Benetos,
P. Lacolley
et al.
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148
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| Poster Presentation Abstracts |
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Article Title |
Author(s) |
Pages |
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Which one is more important in prognosis between carotid intima-media thickness and carotid plaque?
Background and Objectives: Carotid intima-media thickness (CIMT) and plaque are both important in primary prevention. However, it is still unclear which one is more important in prognosis in patients ...
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T.G. Kwon,
K.H. Kim,
W.H. Kim,
D.J. Yang,
J.H. Bae
et al.
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149
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Aortic stiffness measurement improves the prediction of asymptomatic coronary artery disease in stroke/TIA patients
Background: Aortic stiffness is an independent predictor of coronary events. We assessed the predictive value of aortic stiffness for ≥50% asymptomatic coronary artery disease (CAD) in a stroke popula...
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D. Calvet,
E. Touzé,
S. Laurent,
J.L. Sablayrolles,
P. Boutouyrie,
J.L. Mas
et al.
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149
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Systolic time intervals derived from carotid artery distension waveforms for integrated cardiovascular risk assessment
Background: Circulatory biomechanics dictate that, with given arterial compliance and pulse pressure, left ventricular ejection and isovolumic-contraction durations (Tej and Tic) reflect systolic vent...
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K. Reesink,
P. Boutouyrie,
P. Brands
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149-150
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Effect of aging on the annual changes of central hemodynamic indices in middle-aged men: A prospective evaluation
Objective: To examine the effects of aging on the annual changes of the pressure wave reflection (PWR) and central blood pressures (CBPs), prospectively. Background: Such prospective study has not bee...
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H. Tomiyama,
A. Yamashina
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150
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Blood pressure variability in relation to autonomic nervous system dysregulation: The X-CELLENT study
To investigate the association of autonomic nervous system dysregulation with blood pressure variability. Of 2370 participants in the X-CELLENT study, 577 patients (59.0±10.2 years) were randomly sele...
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Y. Zhang,
D. Agnoletti,
J. Blacher,
M.E. Safar
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150
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Carotid function and baroreceptor sensitivity in moderate chronic kidney disease: The EPP3 study
Introduction: Short-term variation of blood pressure (BP) is largely controlled by autonomic function though the baroreflex. Carotid distension rate was recently introduced instead of BP to evaluate t...
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L. Zanoli,
M. Alivon,
N. Estrugo,
G. Ecriou,
H. Ketthab,
J.F. Pruny,
P. Castellino,
S. Yanes,
D. Laude,
K. Bean,
F. Thomas,
J.P. Empana,
X. Jouven,
S. Laurent,
P. Boutouyrie
et al.
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150-151
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The role of pulse pressure for cognitive decline in hypertension
Objective: Pulse pressure (PP), as a marker of large artery stiffness, is a risk factor for target organ damage in hypertension (HT). We hypothesized that elevated PP, as a marker of enhanced arterial...
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T. Yaneva,
R. Tarnovska,
L. Traykov
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151
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Relation of central and brachial blood pressure to ECG left ventricular hypertrophy. The Czech post-MONICA study
Objective: Central blood pressure (BP) has been shown to be a better predictor of target organ damage and cardiovascular events than brachial BP. Whether central BP is a better predictor of left ventr...
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P. Wohlfahrt,
D. Wichterle,
J. Seidlerova,
J. Filipovsky,
R. Cifkova
et al.
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151
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Prevalence of resistant hypertension in a general population in northern Italy: Associated cardiovascular risk factors and target organ damage
Background: Resistant hypertension (RH) is defined by most guidelines as blood pressure that remains above goal despite use of at least 3 antihypertensive agents of different classes, including a diur...
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M. Salvetti,
M.L. Muiesan,
A. Paini,
C. Agabiti Rosei,
C. Aggiusti,
F. Bertacchini,
D. Stassaldi,
F. Beschi,
G. Rubagotti,
C. Monteduro,
M. Castellano,
E. Agabiti Rosei
et al.
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151
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Increased age, body mass index and low HDL-C levels relate to an echolucent structure of the carotid intima–media thickness: The METEOR study
Introduction: Echolucent plaques have high lipid contents and are related to a higher cardiovascular risk. Studies relating echolucency to cardiovascular risk in early stages of atherosclerosis are li...
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S.A.E. Peters,
L. Lind,
H.M. den Ruijter,
M.K. Palmer,
D.E. Grobbee,
J.R. Crouse,
D.H. O'Leary,
G.W. Evans,
J.S. Raichlen,
M.L. Bots
et al.
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151
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B-proof: Is arterial stiffening associated with homocysteine?
Introduction: Recently in elderly, homocysteine alone has been shown to be a better predictor of cardiovascular mortality than models based on classical risk factors. The pathophysiological pathway is...
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S.C. van Dijk,
A.H. van den Meiracker,
F.U.S. Mattace-Raso,
N. van der Velde
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151-152
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Central blood pressure (BP) is an independent predictor of worse outcome in young to middle age subjects screened for stage I hypertension
Objective: The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied ...
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F. Saladini,
E. Benetti,
M. Santonastaso,
L. Mos,
S. Cozzio,
G. Garavelli,
A. Bortolazzi,
P. Palatini
et al.
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152
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Formation of new atherosclerotic plaques in well controlled rheumatoid arthritis depends on classical cardiovascular risk factors: A prospective longitudinal study
Background: Rheumatoid arthritis (RA) is an independent risk factor for cardiovascular disease (CVD); RA patients demonstrate advanced pre-clinical carotid atherosclerosis compared to controls.
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A.D. Protogerou,
E. Zampeli,
K. Stamatelopoulos,
K. Fragiadaki,
C.G. Katsiari,
K. Kyrkou,
C.M. Papamichael,
M. Mavrikakis,
G.D. Kitas,
P.P. Sfikakis
et al.
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152
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Central blood pressure (CBP) measurements in the Portuguese population: The Guimarães study (study to determine the cardiovascular risk of the population of Guimarães/Vizela: Prevalence of arterial stiffness and early vascular aging syndrome)
We observed 1104 subjects of the Portuguese population coming from two northern adjacent cities: Guimarães and Vizela. They were randomly selected to be included in a cohort representative of age and ...
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P.G. Cunha,
P.N. Oliveira,
J. Cotter,
N. Sousa
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152
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Relationship between media to lumen ratio of subcutaneous small arteries and wall to lumen ratio of retinal arterioles evaluated non invasively by scanning laser Doppler flowmetry
Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media to lumen (M/L) ratio, are frequently present in hypertensive and/or diabetic patients, and may repr...
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D. Rizzoni,
E. Porteri,
C. De Ciuceis,
E. La Boria,
S. Duse,
F. Semeraro,
C. Costagliola,
A. Sebastiani,
P. Danzi,
G.A.M. Tiberio,
S.M. Giulini,
C. Agabiti Rosei,
A. Sarkar,
D. Avanzi,
E. Agabiti Rosei
et al.
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152-153
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